Mitochondrial import inner membrane translocase subunit TIM16 (PAM16)
Homo sapiens — UniProt Q9Y3D7
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) is a protein from Homo sapiens identified by UniProt accession Q9Y3D7, 125 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9Y3D7; gene symbol PAM16.
- Organism: Homo sapiens.
- Length: 125 amino acids.
- Top disease associations (Open Targets): Autosomal recessive spondylometaphyseal dysplasia, Mégarbané type, autosomal recessive spondylometaphyseal dysplasia, Megarbane type and nephronophthisis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial import inner membrane translocase subunit TIM16 |
|---|---|
| UniProt accession | Q9Y3D7 |
| Gene | PAM16 |
| Organism | Homo sapiens |
| Length | 125 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- Autosomal recessive spondylometaphyseal dysplasia, Mégarbané type · score 0.55
- autosomal recessive spondylometaphyseal dysplasia, Megarbane type · score 0.53
- nephronophthisis · score 0.49
- neurodegenerative disease · score 0.32
- lysosomal storage disease · score 0.32
- multiple sclerosis · score 0.32
- Alzheimer disease · score 0.32
- Parkinson disease · score 0.32
- acute megakaryoblastic leukaemia · score 0.11
- mediastinal germ cell tumor · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3D7-F1 | alphafold | PREDICTED | 89.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3D7.
Amino-acid sequence (125 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PAM16?
The strongest Open Targets associations for PAM16 are Autosomal recessive spondylometaphyseal dysplasia, Mégarbané type, autosomal recessive spondylometaphyseal dysplasia, Megarbane type, nephronophthisis, neurodegenerative disease and lysosomal storage disease.
How long is the PAM16 protein?
The Homo sapiens PAM16 protein (UniProt Q9Y3D7) is 125 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3D7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3D7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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