Hepatoma-derived growth factor-related protein 3 (HDGFL3)
Homo sapiens — UniProt Q9Y3E1
Data last refreshed: (UniProt release unknown)
Key facts
Hepatoma-derived growth factor-related protein 3 (HDGFL3) is a protein from Homo sapiens identified by UniProt accession Q9Y3E1, 203 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q9Y3E1; gene symbol HDGFL3.
- Organism: Homo sapiens.
- Length: 203 amino acids.
- Top disease associations (Open Targets): lymphocyte count, smoking status measurement and hair colour measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hepatoma-derived growth factor-related protein 3 |
|---|---|
| UniProt accession | Q9Y3E1 |
| Gene | HDGFL3 |
| Organism | Homo sapiens |
| Length | 203 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.36
- smoking status measurement · score 0.16
- hair colour measurement · score 0.16
- substance abuse · score 0.16
- attention deficit hyperactivity disorder · score 0.16
- antisocial behaviour measurement · score 0.16
- age at menopause · score 0.14
- hair color · score 0.14
- protein measurement · score 0.12
- bipolar disorder · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3E1-F1 | alphafold | PREDICTED | 70.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3E1.
Amino-acid sequence (203 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HDGFL3?
The strongest Open Targets associations for HDGFL3 are lymphocyte count, smoking status measurement, hair colour measurement, substance abuse and attention deficit hyperactivity disorder.
How long is the HDGFL3 protein?
The Homo sapiens HDGFL3 protein (UniProt Q9Y3E1) is 203 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3E1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3E1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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