Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2)
Homo sapiens — UniProt Q9Y3E5
Data last refreshed: (UniProt release unknown)
Key facts
Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2) is a protein from Homo sapiens identified by UniProt accession Q9Y3E5, 179 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.
- UniProt accession: Q9Y3E5; gene symbol PTRH2.
- Organism: Homo sapiens.
- Length: 179 amino acids.
- Top disease associations (Open Targets): neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1, neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset and intellectual disability, autosomal dominant 56.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Peptidyl-tRNA hydrolase 2, mitochondrial |
|---|---|
| UniProt accession | Q9Y3E5 |
| Gene | PTRH2 |
| Organism | Homo sapiens |
| Length | 179 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (97)
Diseases linked to this target (Open Targets).
- neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1 · score 0.69
- neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset · score 0.54
- intellectual disability, autosomal dominant 56 · score 0.27
- Global developmental delay · score 0.26
- Hearing impairment · score 0.26
- cerebellar ataxia · score 0.26
- breast adenocarcinoma · score 0.23
- genetic disorder · score 0.18
- leukocyte count · score 0.11
- neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3E5-F1 | alphafold | PREDICTED | 83.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3E5.
Amino-acid sequence (179 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PTRH2?
The strongest Open Targets associations for PTRH2 are neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1, neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset, intellectual disability, autosomal dominant 56, Global developmental delay and Hearing impairment.
How long is the PTRH2 protein?
The Homo sapiens PTRH2 protein (UniProt Q9Y3E5) is 179 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3E5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3E5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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