RNA-splicing ligase RTCB (RTCB)
Homo sapiens — UniProt Q9Y3I0
Data last refreshed: (UniProt release unknown)
Key facts
RNA-splicing ligase RTCB (RTCB) is a protein from Homo sapiens identified by UniProt accession Q9Y3I0, 505 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q9Y3I0; gene symbol RTCB.
- Organism: Homo sapiens.
- Length: 505 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and adolescent idiopathic scoliosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA-splicing ligase RTCB |
|---|---|
| UniProt accession | Q9Y3I0 |
| Gene | RTCB |
| Organism | Homo sapiens |
| Length | 505 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- lysosomal storage disease · score 0.17
- adolescent idiopathic scoliosis · score 0.15
- acne · score 0.04
- FEV/FVC ratio · score 0.04
- mean corpuscular volume · score 0.03
- systemic juvenile idiopathic arthritis · score 0.02
- cancer · score 0.02
- breast cancer · score 0.01
- colitis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3I0-F1 | alphafold | PREDICTED | 95.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3I0.
Amino-acid sequence (505 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RTCB?
The strongest Open Targets associations for RTCB are neurodegenerative disease, lysosomal storage disease, adolescent idiopathic scoliosis, acne and FEV/FVC ratio.
How long is the RTCB protein?
The Homo sapiens RTCB protein (UniProt Q9Y3I0) is 505 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3I0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3I0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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