SH3 domain-binding protein 1 (SH3BP1)
Homo sapiens — UniProt Q9Y3L3
Data last refreshed: (UniProt release unknown)
Key facts
SH3 domain-binding protein 1 (SH3BP1) is a protein from Homo sapiens identified by UniProt accession Q9Y3L3, 701 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q9Y3L3; gene symbol SH3BP1.
- Organism: Homo sapiens.
- Length: 701 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, myeloid white cell count and serum albumin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH3 domain-binding protein 1 |
|---|---|
| UniProt accession | Q9Y3L3 |
| Gene | SH3BP1 |
| Organism | Homo sapiens |
| Length | 701 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- myeloid white cell count · score 0.19
- serum albumin measurement · score 0.17
- reticulocyte measurement · score 0.10
- leukocyte count · score 0.08
- mean corpuscular volume · score 0.04
- acute myeloid leukemia · score 0.03
- blood protein measurement · score 0.02
- mean platelet volume · score 0.02
- body height · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3L3-F1 | alphafold | PREDICTED | 70.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3L3.
Amino-acid sequence (701 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH3BP1?
The strongest Open Targets associations for SH3BP1 are neurodegenerative disease, myeloid white cell count, serum albumin measurement, reticulocyte measurement and leukocyte count.
How long is the SH3BP1 protein?
The Homo sapiens SH3BP1 protein (UniProt Q9Y3L3) is 701 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3L3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3L3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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