Signaling threshold-regulating transmembrane adapter 1 (SIT1)
Homo sapiens — UniProt Q9Y3P8
Data last refreshed: (UniProt release unknown)
Key facts
Signaling threshold-regulating transmembrane adapter 1 (SIT1) is a protein from Homo sapiens identified by UniProt accession Q9Y3P8, 196 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q9Y3P8; gene symbol SIT1.
- Organism: Homo sapiens.
- Length: 196 amino acids.
- Top disease associations (Open Targets): autoimmune disease, psoriasis and Hashimoto's thyroiditis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Signaling threshold-regulating transmembrane adapter 1 |
|---|---|
| UniProt accession | Q9Y3P8 |
| Gene | SIT1 |
| Organism | Homo sapiens |
| Length | 196 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- autoimmune disease · score 0.23
- psoriasis · score 0.09
- Hashimoto's thyroiditis · score 0.09
- common variable immunodeficiency · score 0.05
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.05
- immunodeficiency 72 with autoinflammation · score 0.05
- autoimmune lymphoproliferative syndrome · score 0.05
- T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.05
- short-limb skeletal dysplasia with severe combined immunodeficiency · score 0.05
- gamma chain deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3P8-F1 | alphafold | PREDICTED | 60.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3P8.
Amino-acid sequence (196 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIT1?
The strongest Open Targets associations for SIT1 are autoimmune disease, psoriasis, Hashimoto's thyroiditis, common variable immunodeficiency and immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias.
How long is the SIT1 protein?
The Homo sapiens SIT1 protein (UniProt Q9Y3P8) is 196 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3P8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3P8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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