Disintegrin and metalloproteinase domain-containing protein 18 (ADAM18)
Homo sapiens — UniProt Q9Y3Q7
Data last refreshed: (UniProt release unknown)
Key facts
Disintegrin and metalloproteinase domain-containing protein 18 (ADAM18) is a protein from Homo sapiens identified by UniProt accession Q9Y3Q7, 739 residues long. MolForge cross-references it against 0 known binders and 2 disease associations.
- UniProt accession: Q9Y3Q7; gene symbol ADAM18.
- Organism: Homo sapiens.
- Length: 739 amino acids.
- Top disease associations (Open Targets): squamous cell carcinoma and Sjogren syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Disintegrin and metalloproteinase domain-containing protein 18 |
|---|---|
| UniProt accession | Q9Y3Q7 |
| Gene | ADAM18 |
| Organism | Homo sapiens |
| Length | 739 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (2)
Diseases linked to this target (Open Targets).
- squamous cell carcinoma · score 0.00
- Sjogren syndrome · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3Q7-F1 | alphafold | PREDICTED | 78.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3Q7.
Amino-acid sequence (739 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAM18?
The strongest Open Targets associations for ADAM18 are squamous cell carcinoma and Sjogren syndrome.
How long is the ADAM18 protein?
The Homo sapiens ADAM18 protein (UniProt Q9Y3Q7) is 739 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3Q7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3Q7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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