Sialidase-2 (NEU2)
Homo sapiens — UniProt Q9Y3R4
Data last refreshed: (UniProt release unknown)
Key facts
Sialidase-2 (NEU2) is a protein from Homo sapiens identified by UniProt accession Q9Y3R4, 380 residues long. MolForge cross-references it against 2 known binders and 63 disease associations.
- UniProt accession: Q9Y3R4; gene symbol NEU2.
- Organism: Homo sapiens.
- Length: 380 amino acids.
- Top disease associations (Open Targets): bilirubin measurement, body height and neuroticism measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sialidase-2 |
|---|---|
| UniProt accession | Q9Y3R4 |
| Gene | NEU2 |
| Organism | Homo sapiens |
| Length | 380 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.46
- body height · score 0.25
- neuroticism measurement · score 0.08
- neoplasm · score 0.06
- pancreatic neoplasm · score 0.05
- citrullinemia type II · score 0.04
- Alzheimer disease · score 0.04
- family history of Alzheimer’s disease · score 0.04
- neonatal intrahepatic cholestasis due to citrin deficiency · score 0.04
- glycogen storage disease VI · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3R4-F1 | alphafold | PREDICTED | 97.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3R4.
Amino-acid sequence (380 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NEU2?
The strongest Open Targets associations for NEU2 are bilirubin measurement, body height, neuroticism measurement, neoplasm and pancreatic neoplasm.
How long is the NEU2 protein?
The Homo sapiens NEU2 protein (UniProt Q9Y3R4) is 380 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3R4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3R4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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