Protein DOP1B (DOP1B)

Homo sapiens — UniProt Q9Y3R5

Gene: DOP1BHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Protein DOP1B (DOP1B) is a protein from Homo sapiens identified by UniProt accession Q9Y3R5, 2298 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

UniProt accession: Q9Y3R5; gene symbol DOP1B.
Organism: Homo sapiens.
Length: 2298 amino acids.
Top disease associations (Open Targets): low density lipoprotein cholesterol measurement, PHF-tau measurement and blood protein measurement.
3D structure: AlphaFold model available.

Target properties

Protein name	Protein DOP1B
UniProt accession	Q9Y3R5
Gene	DOP1B
Organism	Homo sapiens
Length	2298 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

low density lipoprotein cholesterol measurement · score 0.37
PHF-tau measurement · score 0.29
blood protein measurement · score 0.23
hemoglobin measurement · score 0.13
hematocrit · score 0.13
keratoconus · score 0.11
lymphocyte count · score 0.10
body height · score 0.07
vital capacity · score 0.06
leukocyte count · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y3R5-F1	alphafold	PREDICTED	71.78	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3R5.

Amino-acid sequence (2298 residues)

MDPEEQELLN DYRYRSYSSV IEKALRNFES SSEWADLISS LGKLNKALQS NLRYSLLPRR LLISKRLAQC LHPALPSGVH LKALETYEII FKIVGTKWLA KDLFLYSCGL FPLLAHAAVS VRPVLLTLYE KYFLPLQKLL LPSLQAFIVG LLPGLEEGSE ISDRTDALLL RLSLVVGKEV FYTALWGSVL ASPSIRLPAS VFVVGHINRD APGREQKYML GTNHQLTVKS LRASLLDSNV LVQRNNLEIV LFFFPFYTCL DSNERAIPLL RSDIVRILSA ATQTLLRRDM SLNRRLYAWL LGSDIKGNTV VPESEISNSY EDQSSYFFEK YSKDLLVEGL AEILHQKFID ADVEERHHAY LKPFRVLISL LDKPEIGPQV VGNLFLEVIR AFYSYCRDAL GSDLKLSYTQ SGNSLISAIK ENRNASEIVK TVNLLITSLS TDFLWDYMTR CFEECFRPVK QRYSVRNSVS PPPTVSELCA LLVFLLDVIP LELYSEVQTQ YLPQVLGCLV QPLAEDMEAL SLPELTHALK TCFKVLSKVQ MPPSYLDTES TSGTSSPVKG ENGKIILETK AVIPGDEDAS FPPLKSEDSG IGLSASSPEL SEHLRVPRVS LERDDVWKKG GSMQRTFLCI QELIANFASK NIFGVQLTAS GEESKSEEPA GKRDRDGTQS LAANDSSRKN SWEPKPITVP QFKQMLSDLF TARGSPFKTK SSESPSSSPS SPARKNGGEW DVEKVVIDLG GSREERREAF AAACHLLLDC ATFPVYLSEE ETEQLCATLF QLPGAGDSSF PSWLKSLMTI CCCVTDCYLQ NVAISTLLEV INHSQSLALV IEDKMKRYKS SGHNPFFGKL QMVTVPPIAP GILKVIAEKT DFYQRVARVL WNQLNKETRE HHVTCVELFY RLHCLAPTAN ICEDIICHAL LDPDKGTRLE ALFRFSVIWH LTREIQGSRV TSHNRSFDRS LFVVLDSLAC TDGAIGAAAQ GWLVRALSLG DVARILEPVL LLLLQPKTQR TSIHCLKQEN SADDLHRWFN RKKTSFREAC AVPEPQESGS EEHLPLSQFT TVDREAIWAE VEKEPEKYPL RGELSEEELP YYVELPDRTA HGAPDSSEHT ESADTSSCHT DSENTSSFSS PSHDLQELSN EENCCAPIPM GGRAYPKRSA LLAAFQSESF KAGAKLSLVR VDSDKTQASE SFSSDEEADL ELQALTTSRL LKQQRERQEA VEALFKHILL YLQPYDSRRV LYAFSVLEAV LKTNPKEFIE AVSRTSMDTS STAHLNLISN LLARHQEALI GQSFYGKLQT QVPNVCPHSL LLELLTYLCL SFLRSYYPCY LKVSHRDILG NRDVQVKSVE VLIRIMMQLV SVAKSSEGKN VEFIHSLLQR CKVQEFVLLS LSASMYTSQK RYGLATAHHG RALPEDSLFE ESLINLGQDQ IWSEHPLQIE LLKLLQVLIV LEHHLGRAHE EAENQPDLSR EWQRALNFQQ AISALQYVQP HPLTSQGLLV SAVVRGLQPA YGYGMHPAWV SLVTHSLPYF GKSLGWTVTP FVVQICKNLD DLVKQYESES VKLSVSTTSK RENISPDYPL TLLEGLTTIS HFCLLEQANQ NKKTMAAGDP ANLRNARNAI LEELPRTVNT MALLWNVLRK EETQKRPVDL LGATKGSSSV YFKTTKTIRQ KILDFLNPLT AHLGVQLTAA VAAVWSRKKA QRHSKMKIIP TASASQLTLV DLVCALSTLQ TDTLLHLVKE VVKRPPQVKG GDEKSPLVDI PVLQFCYAFL QRLPVPALQE NFSSLLGVLK ESVQLNLAPP GYFLLLSMLN DFVTRTPNLE NKKDQKDLQE ITQKILEAVG NIAGSSLEQT SWLSRNLEVK AQPQASLEES DAEEDLYDAA AASAMVSSSA PSVYSVQALS LLAEVLASLL DMVYRSDEKE KAVPLISRLL YYVFPYLRNH SAYNAPSFRA GAQLLSSLSG YAYTKRAWRK EVLELFLDPA FFQMDTSCVH WKSIIDHLLT HEKTMFKDLM NMQSSSLKLF SSFEQKAMLL KRQAFAVFSG ELDQYHLYLP LIQERLTDNL RVGQTSIVAA QMFLFFRVLL LRISPQHLTS LWPIMVSELI QTFTQLEEDL KDEDESLRST NKVNRTKVSV PDANGPSVGE IPQSELILYL SACKFLDTAL SFPPDKMPLF QIYRWAFIPE VDTEGPAFLS DVEENHQECK PHTVRILELL KLKFGEISSS DEITMKSEFP LLRQHSVSSI RQLMPFFMTL NGAFKTQRQL PADSPGTPFL DFPVTDSPRI LKQLEECIEY DFLEHPEC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with DOP1B?

The strongest Open Targets associations for DOP1B are low density lipoprotein cholesterol measurement, PHF-tau measurement, blood protein measurement, hemoglobin measurement and hematocrit.

How long is the DOP1B protein?

The Homo sapiens DOP1B protein (UniProt Q9Y3R5) is 2298 amino acids long.

Browse: Targets: D · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9Y3R5 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9Y3R5 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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