Chromatin target of PRMT1 protein (CHTOP)
Homo sapiens — UniProt Q9Y3Y2
Data last refreshed: (UniProt release unknown)
Key facts
Chromatin target of PRMT1 protein (CHTOP) is a protein from Homo sapiens identified by UniProt accession Q9Y3Y2, 248 residues long. MolForge cross-references it against 0 known binders and 146 disease associations.
- UniProt accession: Q9Y3Y2; gene symbol CHTOP.
- Organism: Homo sapiens.
- Length: 248 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, platelet count and platelet crit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Chromatin target of PRMT1 protein |
|---|---|
| UniProt accession | Q9Y3Y2 |
| Gene | CHTOP |
| Organism | Homo sapiens |
| Length | 248 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (146)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- platelet count · score 0.16
- platelet crit · score 0.15
- chondrocalcinosis 2 · score 0.05
- 8q24.3 microdeletion syndrome · score 0.04
- 22q11.2 deletion syndrome · score 0.04
- pancreatic hypoplasia-diabetes-congenital heart disease syndrome · score 0.04
- Kabuki syndrome · score 0.04
- Peters plus syndrome · score 0.04
- alveolar capillary dysplasia with misalignment of pulmonary veins · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3Y2-F1 | alphafold | PREDICTED | 61.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3Y2.
Amino-acid sequence (248 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHTOP?
The strongest Open Targets associations for CHTOP are neurodegenerative disease, platelet count, platelet crit, chondrocalcinosis 2 and 8q24.3 microdeletion syndrome.
How long is the CHTOP protein?
The Homo sapiens CHTOP protein (UniProt Q9Y3Y2) is 248 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3Y2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3Y2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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