Pygopus homolog 1 (PYGO1)
Homo sapiens — UniProt Q9Y3Y4
Data last refreshed: (UniProt release unknown)
Key facts
Pygopus homolog 1 (PYGO1) is a protein from Homo sapiens identified by UniProt accession Q9Y3Y4, 419 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q9Y3Y4; gene symbol PYGO1.
- Organism: Homo sapiens.
- Length: 419 amino acids.
- Top disease associations (Open Targets): PHF-tau measurement, endometrial cancer and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pygopus homolog 1 |
|---|---|
| UniProt accession | Q9Y3Y4 |
| Gene | PYGO1 |
| Organism | Homo sapiens |
| Length | 419 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.31
- endometrial cancer · score 0.23
- hepatocellular carcinoma · score 0.13
- appendicular lean mass · score 0.11
- head and neck squamous cell carcinoma · score 0.10
- anti-drug antibody measurement · score 0.06
- response to interferon-beta · score 0.06
- non-small cell lung carcinoma · score 0.04
- risk-taking behaviour · score 0.03
- cortical surface area measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3Y4-F1 | alphafold | PREDICTED | 55.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3Y4.
Amino-acid sequence (419 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PYGO1?
The strongest Open Targets associations for PYGO1 are PHF-tau measurement, endometrial cancer, hepatocellular carcinoma, appendicular lean mass and head and neck squamous cell carcinoma.
How long is the PYGO1 protein?
The Homo sapiens PYGO1 protein (UniProt Q9Y3Y4) is 419 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3Y4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3Y4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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