Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1)
Homo sapiens — UniProt Q9Y3Z3
Data last refreshed: (UniProt release unknown)
Key facts
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) is a protein from Homo sapiens identified by UniProt accession Q9Y3Z3, 626 residues long. MolForge cross-references it against 0 known binders and 209 disease associations.
- UniProt accession: Q9Y3Z3; gene symbol SAMHD1.
- Organism: Homo sapiens.
- Length: 626 amino acids.
- Top disease associations (Open Targets): Aicardi-Goutières syndrome, Aicardi-Goutieres syndrome and telomere length.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
|---|---|
| UniProt accession | Q9Y3Z3 |
| Gene | SAMHD1 |
| Organism | Homo sapiens |
| Length | 626 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (209)
Diseases linked to this target (Open Targets).
- Aicardi-Goutières syndrome · score 0.82
- Aicardi-Goutieres syndrome · score 0.73
- telomere length · score 0.59
- neoplasm · score 0.53
- chilblain lupus · score 0.48
- body height · score 0.39
- lean body mass · score 0.37
- familial chilblain lupus · score 0.37
- Moyamoya disease · score 0.37
- Seizure · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3Z3-F1 | alphafold | PREDICTED | 88.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3Z3.
Amino-acid sequence (626 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SAMHD1?
The strongest Open Targets associations for SAMHD1 are Aicardi-Goutières syndrome, Aicardi-Goutieres syndrome, telomere length, neoplasm and chilblain lupus.
How long is the SAMHD1 protein?
The Homo sapiens SAMHD1 protein (UniProt Q9Y3Z3) is 626 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3Z3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3Z3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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