Nuclear factor erythroid 2-related factor 3 (NFE2L3)
Homo sapiens — UniProt Q9Y4A8
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear factor erythroid 2-related factor 3 (NFE2L3) is a protein from Homo sapiens identified by UniProt accession Q9Y4A8, 694 residues long. MolForge cross-references it against 0 known binders and 165 disease associations.
- UniProt accession: Q9Y4A8; gene symbol NFE2L3.
- Organism: Homo sapiens.
- Length: 694 amino acids.
- Top disease associations (Open Targets): lymphocyte count, low density lipoprotein cholesterol measurement and total cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear factor erythroid 2-related factor 3 |
|---|---|
| UniProt accession | Q9Y4A8 |
| Gene | NFE2L3 |
| Organism | Homo sapiens |
| Length | 694 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (165)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.40
- low density lipoprotein cholesterol measurement · score 0.35
- total cholesterol measurement · score 0.33
- body height · score 0.32
- triglyceride measurement · score 0.31
- serum gamma-glutamyl transferase measurement · score 0.30
- BMI-adjusted waist-hip ratio · score 0.30
- BMI-adjusted waist circumference · score 0.30
- physical activity measurement · score 0.29
- interleukin 18 measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4A8-F1 | alphafold | PREDICTED | 53.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4A8.
Amino-acid sequence (694 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NFE2L3?
The strongest Open Targets associations for NFE2L3 are lymphocyte count, low density lipoprotein cholesterol measurement, total cholesterol measurement, body height and triglyceride measurement.
How long is the NFE2L3 protein?
The Homo sapiens NFE2L3 protein (UniProt Q9Y4A8) is 694 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4A8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4A8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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