Lysine-specific demethylase 3A (KDM3A)
Homo sapiens — UniProt Q9Y4C1
Data last refreshed: (UniProt release unknown)
Key facts
Lysine-specific demethylase 3A (KDM3A) is a protein from Homo sapiens identified by UniProt accession Q9Y4C1, 1321 residues long. MolForge cross-references it against 0 known binders and 307 disease associations.
- UniProt accession: Q9Y4C1; gene symbol KDM3A.
- Organism: Homo sapiens.
- Length: 1321 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neuroticism measurement and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lysine-specific demethylase 3A |
|---|---|
| UniProt accession | Q9Y4C1 |
| Gene | KDM3A |
| Organism | Homo sapiens |
| Length | 1321 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (307)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- neuroticism measurement · score 0.26
- type 2 diabetes mellitus · score 0.24
- breast adenocarcinoma · score 0.22
- blood protein measurement · score 0.21
- depressive symptom measurement · score 0.21
- wellbeing measurement · score 0.21
- unipolar depression · score 0.20
- attention deficit hyperactivity disorder · score 0.16
- antisocial behaviour measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4C1-F1 | alphafold | PREDICTED | 67.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4C1.
Amino-acid sequence (1321 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KDM3A?
The strongest Open Targets associations for KDM3A are neurodegenerative disease, neuroticism measurement, type 2 diabetes mellitus, breast adenocarcinoma and blood protein measurement.
How long is the KDM3A protein?
The Homo sapiens KDM3A protein (UniProt Q9Y4C1) is 1321 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4C1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4C1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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