TRPM8 channel-associated factor 1 (TCAF1)
Homo sapiens — UniProt Q9Y4C2
Data last refreshed: (UniProt release unknown)
Key facts
TRPM8 channel-associated factor 1 (TCAF1) is a protein from Homo sapiens identified by UniProt accession Q9Y4C2, 921 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q9Y4C2; gene symbol TCAF1.
- Organism: Homo sapiens.
- Length: 921 amino acids.
- Top disease associations (Open Targets): neoplasm, cancer and psoriasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TRPM8 channel-associated factor 1 |
|---|---|
| UniProt accession | Q9Y4C2 |
| Gene | TCAF1 |
| Organism | Homo sapiens |
| Length | 921 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.01
- cancer · score 0.01
- psoriasis · score 0.01
- gastrointestinal stromal tumor · score 0.01
- juvenile dermatomyositis · score 0.00
- lung adenocarcinoma · score 0.00
- prostatitis · score 0.00
- glioblastoma multiforme · score 0.00
- dental caries · score 0.00
- chronic kidney disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4C2-F1 | alphafold | PREDICTED | 92.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4C2.
Amino-acid sequence (921 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TCAF1?
The strongest Open Targets associations for TCAF1 are neoplasm, cancer, psoriasis, gastrointestinal stromal tumor and juvenile dermatomyositis.
How long is the TCAF1 protein?
The Homo sapiens TCAF1 protein (UniProt Q9Y4C2) is 921 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4C2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4C2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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