Disheveled-associated activator of morphogenesis 1 (DAAM1)
Homo sapiens — UniProt Q9Y4D1
Data last refreshed: (UniProt release unknown)
Key facts
Disheveled-associated activator of morphogenesis 1 (DAAM1) is a protein from Homo sapiens identified by UniProt accession Q9Y4D1, 1078 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.
- UniProt accession: Q9Y4D1; gene symbol DAAM1.
- Organism: Homo sapiens.
- Length: 1078 amino acids.
- Top disease associations (Open Targets): brain volume measurement, cortical surface area measurement and cortical thickness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Disheveled-associated activator of morphogenesis 1 |
|---|---|
| UniProt accession | Q9Y4D1 |
| Gene | DAAM1 |
| Organism | Homo sapiens |
| Length | 1078 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (92)
Diseases linked to this target (Open Targets).
- brain volume measurement · score 0.43
- cortical surface area measurement · score 0.42
- cortical thickness · score 0.36
- brain measurement · score 0.34
- neuroimaging measurement · score 0.32
- body height · score 0.29
- neurofibrillary tangles measurement · score 0.28
- visual cortical surface area measurement · score 0.26
- retinal nerve fibre layer thickness measurement · score 0.26
- retinal layer thickness measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4D1-F1 | alphafold | PREDICTED | 80.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4D1.
Amino-acid sequence (1078 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DAAM1?
The strongest Open Targets associations for DAAM1 are brain volume measurement, cortical surface area measurement, cortical thickness, brain measurement and neuroimaging measurement.
How long is the DAAM1 protein?
The Homo sapiens DAAM1 protein (UniProt Q9Y4D1) is 1078 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4D1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4D1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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