E3 SUMO-protein ligase ZNF451 (ZNF451)
Homo sapiens — UniProt Q9Y4E5
Data last refreshed: (UniProt release unknown)
Key facts
E3 SUMO-protein ligase ZNF451 (ZNF451) is a protein from Homo sapiens identified by UniProt accession Q9Y4E5, 1061 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q9Y4E5; gene symbol ZNF451.
- Organism: Homo sapiens.
- Length: 1061 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, telomere length and pemphigus foliaceus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 SUMO-protein ligase ZNF451 |
|---|---|
| UniProt accession | Q9Y4E5 |
| Gene | ZNF451 |
| Organism | Homo sapiens |
| Length | 1061 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- telomere length · score 0.25
- pemphigus foliaceus · score 0.07
- neoplasm · score 0.03
- lymphocyte count · score 0.03
- Bloom syndrome · score 0.03
- pulmonary fibrosis · score 0.03
- immature platelet fraction · score 0.03
- leukocyte count · score 0.02
- acute myeloid leukemia · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4E5-F1 | alphafold | PREDICTED | 68.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4E5.
Amino-acid sequence (1061 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF451?
The strongest Open Targets associations for ZNF451 are neurodegenerative disease, telomere length, pemphigus foliaceus, neoplasm and lymphocyte count.
How long is the ZNF451 protein?
The Homo sapiens ZNF451 protein (UniProt Q9Y4E5) is 1061 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4E5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4E5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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