Ubiquitin carboxyl-terminal hydrolase 15 (USP15)
Homo sapiens — UniProt Q9Y4E8
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 15 (USP15) is a protein from Homo sapiens identified by UniProt accession Q9Y4E8, 981 residues long. MolForge cross-references it against 0 known binders and 171 disease associations.
- UniProt accession: Q9Y4E8; gene symbol USP15.
- Organism: Homo sapiens.
- Length: 981 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, eosinophil count and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 15 |
|---|---|
| UniProt accession | Q9Y4E8 |
| Gene | USP15 |
| Organism | Homo sapiens |
| Length | 981 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (171)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- eosinophil count · score 0.38
- platelet count · score 0.36
- platelet crit · score 0.33
- aortic measurement · score 0.31
- smoking status measurement · score 0.30
- pancreatic adenocarcinoma · score 0.28
- self reported educational attainment · score 0.26
- glioblastoma multiforme · score 0.25
- ovarian cancer · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4E8-F1 | alphafold | PREDICTED | 75.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4E8.
Amino-acid sequence (981 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP15?
The strongest Open Targets associations for USP15 are neurodegenerative disease, eosinophil count, platelet count, platelet crit and aortic measurement.
How long is the USP15 protein?
The Homo sapiens USP15 protein (UniProt Q9Y4E8) is 981 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4E8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4E8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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