Insulin receptor substrate 2 (IRS2)
Homo sapiens — UniProt Q9Y4H2
Data last refreshed: (UniProt release unknown)
Key facts
Insulin receptor substrate 2 (IRS2) is a protein from Homo sapiens identified by UniProt accession Q9Y4H2, 1338 residues long. MolForge cross-references it against 0 known binders and 503 disease associations.
- UniProt accession: Q9Y4H2; gene symbol IRS2.
- Organism: Homo sapiens.
- Length: 1338 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular volume and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Insulin receptor substrate 2 |
|---|---|
| UniProt accession | Q9Y4H2 |
| Gene | IRS2 |
| Organism | Homo sapiens |
| Length | 1338 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (503)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- mean corpuscular volume · score 0.52
- Red cell distribution width · score 0.51
- reticulocyte count · score 0.51
- mean corpuscular hemoglobin · score 0.49
- heel bone mineral density · score 0.48
- mean corpuscular hemoglobin concentration · score 0.47
- hemoglobin measurement · score 0.47
- platelet count · score 0.45
- hematocrit · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4H2-F1 | alphafold | PREDICTED | 47.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4H2.
Amino-acid sequence (1338 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IRS2?
The strongest Open Targets associations for IRS2 are neurodegenerative disease, mean corpuscular volume, Red cell distribution width, reticulocyte count and mean corpuscular hemoglobin.
How long is the IRS2 protein?
The Homo sapiens IRS2 protein (UniProt Q9Y4H2) is 1338 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4H2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4H2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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