Dystrobrevin alpha (DTNA)
Homo sapiens — UniProt Q9Y4J8
Data last refreshed: (UniProt release unknown)
Key facts
Dystrobrevin alpha (DTNA) is a protein from Homo sapiens identified by UniProt accession Q9Y4J8, 743 residues long. MolForge cross-references it against 0 known binders and 141 disease associations.
- UniProt accession: Q9Y4J8; gene symbol DTNA.
- Organism: Homo sapiens.
- Length: 743 amino acids.
- Top disease associations (Open Targets): dilated cardiomyopathy, left ventricular noncompaction and Meniere disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dystrobrevin alpha |
|---|---|
| UniProt accession | Q9Y4J8 |
| Gene | DTNA |
| Organism | Homo sapiens |
| Length | 743 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (141)
Diseases linked to this target (Open Targets).
- dilated cardiomyopathy · score 0.33
- left ventricular noncompaction · score 0.32
- Meniere disease · score 0.31
- mathematical ability · score 0.30
- cardiac arrhythmia · score 0.27
- Varicose veins · score 0.23
- PR interval · score 0.23
- chronotype measurement · score 0.23
- metabolite measurement · score 0.20
- Muscular dystrophy · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4J8-F1 | alphafold | PREDICTED | 69.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4J8.
Amino-acid sequence (743 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DTNA?
The strongest Open Targets associations for DTNA are dilated cardiomyopathy, left ventricular noncompaction, Meniere disease, mathematical ability and cardiac arrhythmia.
How long is the DTNA protein?
The Homo sapiens DTNA protein (UniProt Q9Y4J8) is 743 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4J8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4J8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.