Lysyl oxidase homolog 2 (LOXL2)
Homo sapiens — UniProt Q9Y4K0
Data last refreshed: (UniProt release unknown)
Key facts
Lysyl oxidase homolog 2 (LOXL2) is a protein from Homo sapiens identified by UniProt accession Q9Y4K0, 774 residues long. MolForge cross-references it against 3 known binders and 278 disease associations.
- UniProt accession: Q9Y4K0; gene symbol LOXL2.
- Organism: Homo sapiens.
- Length: 774 amino acids.
- Top disease associations (Open Targets): body height, neurodegenerative disease and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lysyl oxidase homolog 2 |
|---|---|
| UniProt accession | Q9Y4K0 |
| Gene | LOXL2 |
| Organism | Homo sapiens |
| Length | 774 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (278)
Diseases linked to this target (Open Targets).
- body height · score 0.45
- neurodegenerative disease · score 0.29
- blood protein measurement · score 0.28
- appendicular lean mass · score 0.25
- lean body mass · score 0.24
- sitting height measurement · score 0.24
- breast adenocarcinoma · score 0.23
- forced expiratory volume · score 0.23
- lung adenocarcinoma · score 0.20
- central corneal thickness · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4K0-F1 | alphafold | PREDICTED | 86.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4K0.
Amino-acid sequence (774 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LOXL2?
The strongest Open Targets associations for LOXL2 are body height, neurodegenerative disease, blood protein measurement, appendicular lean mass and lean body mass.
How long is the LOXL2 protein?
The Homo sapiens LOXL2 protein (UniProt Q9Y4K0) is 774 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4K0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4K0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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