TNF receptor-associated factor 6 (TRAF6)
Homo sapiens — UniProt Q9Y4K3
Data last refreshed: (UniProt release unknown)
Key facts
TNF receptor-associated factor 6 (TRAF6) is a protein from Homo sapiens identified by UniProt accession Q9Y4K3, 522 residues long. MolForge cross-references it against 0 known binders and 555 disease associations.
- UniProt accession: Q9Y4K3; gene symbol TRAF6.
- Organism: Homo sapiens.
- Length: 522 amino acids.
- Top disease associations (Open Targets): severe acute respiratory syndrome, autosomal dominant hypohidrotic ectodermal dysplasia and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TNF receptor-associated factor 6 |
|---|---|
| UniProt accession | Q9Y4K3 |
| Gene | TRAF6 |
| Organism | Homo sapiens |
| Length | 522 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (555)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.37
- autosomal dominant hypohidrotic ectodermal dysplasia · score 0.37
- glioblastoma multiforme · score 0.29
- cystatin C measurement · score 0.29
- breast adenocarcinoma · score 0.27
- ovarian cancer · score 0.25
- lung adenocarcinoma · score 0.24
- gastric adenocarcinoma · score 0.22
- esophageal cancer · score 0.21
- head and neck squamous cell carcinoma · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4K3-F1 | alphafold | PREDICTED | 84.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4K3.
Amino-acid sequence (522 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRAF6?
The strongest Open Targets associations for TRAF6 are severe acute respiratory syndrome, autosomal dominant hypohidrotic ectodermal dysplasia, glioblastoma multiforme, cystatin C measurement and breast adenocarcinoma.
How long is the TRAF6 protein?
The Homo sapiens TRAF6 protein (UniProt Q9Y4K3) is 522 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4K3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4K3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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