Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
Homo sapiens — UniProt Q9Y4K4
Data last refreshed: (UniProt release unknown)
Key facts
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) is a protein from Homo sapiens identified by UniProt accession Q9Y4K4, 846 residues long. MolForge cross-references it against 16 known binders and 116 disease associations.
- UniProt accession: Q9Y4K4; gene symbol MAP4K5.
- Organism: Homo sapiens.
- Length: 846 amino acids.
- Top disease associations (Open Targets): mean platelet volume, hemoglobin measurement and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitogen-activated protein kinase kinase kinase kinase 5 |
|---|---|
| UniProt accession | Q9Y4K4 |
| Gene | MAP4K5 |
| Organism | Homo sapiens |
| Length | 846 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.41
- hemoglobin measurement · score 0.38
- erythrocyte count · score 0.36
- mean corpuscular volume · score 0.36
- serum albumin measurement · score 0.35
- lean body mass · score 0.35
- total blood protein measurement · score 0.34
- body fat distribution · score 0.33
- neurodegenerative disease · score 0.33
- calcium measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4K4-F1 | alphafold | PREDICTED | 73.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4K4.
Amino-acid sequence (846 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAP4K5?
The strongest Open Targets associations for MAP4K5 are mean platelet volume, hemoglobin measurement, erythrocyte count, mean corpuscular volume and serum albumin measurement.
How long is the MAP4K5 protein?
The Homo sapiens MAP4K5 protein (UniProt Q9Y4K4) is 846 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4K4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4K4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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