E3 ubiquitin-protein ligase RNF115 (RNF115)
Homo sapiens — UniProt Q9Y4L5
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF115 (RNF115) is a protein from Homo sapiens identified by UniProt accession Q9Y4L5, 304 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.
- UniProt accession: Q9Y4L5; gene symbol RNF115.
- Organism: Homo sapiens.
- Length: 304 amino acids.
- Top disease associations (Open Targets): clear cell renal carcinoma, platelet count and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF115 |
|---|---|
| UniProt accession | Q9Y4L5 |
| Gene | RNF115 |
| Organism | Homo sapiens |
| Length | 304 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- clear cell renal carcinoma · score 0.18
- platelet count · score 0.18
- diastolic blood pressure · score 0.15
- urate measurement · score 0.13
- breast carcinoma · score 0.11
- uric acid measurement · score 0.10
- neoplasm · score 0.10
- mathematical ability · score 0.10
- lung adenocarcinoma · score 0.07
- MODY · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4L5-F1 | alphafold | PREDICTED | 59.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4L5.
Amino-acid sequence (304 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF115?
The strongest Open Targets associations for RNF115 are clear cell renal carcinoma, platelet count, diastolic blood pressure, urate measurement and breast carcinoma.
How long is the RNF115 protein?
The Homo sapiens RNF115 protein (UniProt Q9Y4L5) is 304 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4L5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4L5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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