WD repeat domain phosphoinositide-interacting protein 2 (WIPI2)
Homo sapiens — UniProt Q9Y4P8
Data last refreshed: (UniProt release unknown)
Key facts
WD repeat domain phosphoinositide-interacting protein 2 (WIPI2) is a protein from Homo sapiens identified by UniProt accession Q9Y4P8, 454 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.
- UniProt accession: Q9Y4P8; gene symbol WIPI2.
- Organism: Homo sapiens.
- Length: 454 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, autosomal recessive non-syndromic intellectual disability and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | WD repeat domain phosphoinositide-interacting protein 2 |
|---|---|
| UniProt accession | Q9Y4P8 |
| Gene | WIPI2 |
| Organism | Homo sapiens |
| Length | 454 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (65)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- autosomal recessive non-syndromic intellectual disability · score 0.53
- lysosomal storage disease · score 0.37
- mean corpuscular hemoglobin concentration · score 0.37
- mean corpuscular volume · score 0.36
- mean corpuscular hemoglobin · score 0.35
- erythrocyte count · score 0.34
- reticulocyte count · score 0.31
- red blood cell density measurement · score 0.29
- Immature Reticulocyte Fraction Measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4P8-F1 | alphafold | PREDICTED | 75.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4P8.
Amino-acid sequence (454 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WIPI2?
The strongest Open Targets associations for WIPI2 are neurodegenerative disease, autosomal recessive non-syndromic intellectual disability, lysosomal storage disease, mean corpuscular hemoglobin concentration and mean corpuscular volume.
How long is the WIPI2 protein?
The Homo sapiens WIPI2 protein (UniProt Q9Y4P8) is 454 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4P8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4P8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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