Sperm flagellar protein 1 (SPEF1)
Homo sapiens — UniProt Q9Y4P9
Data last refreshed: (UniProt release unknown)
Key facts
Sperm flagellar protein 1 (SPEF1) is a protein from Homo sapiens identified by UniProt accession Q9Y4P9, 236 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q9Y4P9; gene symbol SPEF1.
- Organism: Homo sapiens.
- Length: 236 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neutrophil count and neutrophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm flagellar protein 1 |
|---|---|
| UniProt accession | Q9Y4P9 |
| Gene | SPEF1 |
| Organism | Homo sapiens |
| Length | 236 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- neutrophil count · score 0.20
- neutrophil percentage of leukocytes · score 0.14
- lymphocyte percentage of leukocytes · score 0.13
- mean corpuscular volume · score 0.08
- mean reticulocyte volume · score 0.08
- mean corpuscular hemoglobin · score 0.08
- erythrocyte count · score 0.07
- mean corpuscular hemoglobin concentration · score 0.07
- appendicular lean mass · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4P9-F1 | alphafold | PREDICTED | 77.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4P9.
Amino-acid sequence (236 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPEF1?
The strongest Open Targets associations for SPEF1 are neurodegenerative disease, neutrophil count, neutrophil percentage of leukocytes, lymphocyte percentage of leukocytes and mean corpuscular volume.
How long is the SPEF1 protein?
The Homo sapiens SPEF1 protein (UniProt Q9Y4P9) is 236 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4P9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4P9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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