Tubulin monoglycylase TTLL3 (TTLL3)
Homo sapiens — UniProt Q9Y4R7
Data last refreshed: (UniProt release unknown)
Key facts
Tubulin monoglycylase TTLL3 (TTLL3) is a protein from Homo sapiens identified by UniProt accession Q9Y4R7, 772 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9Y4R7; gene symbol TTLL3.
- Organism: Homo sapiens.
- Length: 772 amino acids.
- Top disease associations (Open Targets): genetic disorder, X-linked retinal dysplasia and age-related macular degeneration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tubulin monoglycylase TTLL3 |
|---|---|
| UniProt accession | Q9Y4R7 |
| Gene | TTLL3 |
| Organism | Homo sapiens |
| Length | 772 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.33
- X-linked retinal dysplasia · score 0.07
- age-related macular degeneration · score 0.07
- choroidal dystrophy, central areolar, 1 · score 0.06
- retinitis pigmentosa · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.05
- age related macular degeneration 7 · score 0.05
- age related macular degeneration 4 · score 0.05
- age related macular degeneration 11 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4R7-F1 | alphafold | PREDICTED | 65.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4R7.
Amino-acid sequence (772 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TTLL3?
The strongest Open Targets associations for TTLL3 are genetic disorder, X-linked retinal dysplasia, age-related macular degeneration, choroidal dystrophy, central areolar, 1 and retinitis pigmentosa.
How long is the TTLL3 protein?
The Homo sapiens TTLL3 protein (UniProt Q9Y4R7) is 772 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4R7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4R7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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