Telomere length regulation protein TEL2 homolog (TELO2)
Homo sapiens — UniProt Q9Y4R8
Data last refreshed: (UniProt release unknown)
Key facts
Telomere length regulation protein TEL2 homolog (TELO2) is a protein from Homo sapiens identified by UniProt accession Q9Y4R8, 837 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q9Y4R8; gene symbol TELO2.
- Organism: Homo sapiens.
- Length: 837 amino acids.
- Top disease associations (Open Targets): TELO2-related intellectual disability-neurodevelopmental disorder, neurodegenerative disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Telomere length regulation protein TEL2 homolog |
|---|---|
| UniProt accession | Q9Y4R8 |
| Gene | TELO2 |
| Organism | Homo sapiens |
| Length | 837 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- TELO2-related intellectual disability-neurodevelopmental disorder · score 0.79
- neurodegenerative disease · score 0.47
- lysosomal storage disease · score 0.24
- genetic disorder · score 0.19
- Microcephaly · score 0.11
- rheumatoid arthritis · score 0.10
- heel bone mineral density · score 0.07
- body height · score 0.06
- femoral neck bone mineral density · score 0.04
- sitting height measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4R8-F1 | alphafold | PREDICTED | 83.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4R8.
Amino-acid sequence (837 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TELO2?
The strongest Open Targets associations for TELO2 are TELO2-related intellectual disability-neurodevelopmental disorder, neurodegenerative disease, lysosomal storage disease, genetic disorder and Microcephaly.
How long is the TELO2 protein?
The Homo sapiens TELO2 protein (UniProt Q9Y4R8) is 837 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4R8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4R8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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