Ribosomal biogenesis protein LAS1L (LAS1L)

About Ribosomal biogenesis protein LAS1L

Ribosomal biogenesis protein LAS1L (LAS1L) is a protein from Homo sapiens identified by UniProt accession Q9Y4W2, 734 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Ribosomal biogenesis protein LAS1L
UniProt accession	Q9Y4W2
Gene	LAS1L
Organism	Homo sapiens
Length	734 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

Wilson-Turner syndrome · score 0.63
spinal muscular atrophy with respiratory distress type 2 · score 0.37
genetic disorder · score 0.30
Global developmental delay · score 0.26
Neurodevelopmental disorder · score 0.12
autism spectrum disorder · score 0.12
neurodegenerative disease · score 0.10
serum albumin measurement · score 0.07
liver disease · score 0.07
triple-negative breast cancer · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y4W2-F1	alphafold	PREDICTED	62.51	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4W2.

Amino-acid sequence (734 residues)

MSWESGAGPG LGSQGMDLVW SAWYGKCVKG KGSLPLSAHG IVVAWLSRAE WDQVTVYLFC DDHKLQRYAL NRITVWRSRS GNELPLAVAS TADLIRCKLL DVTGGLGTDE LRLLYGMALV RFVNLISERK TKFAKVPLKC LAQEVNIPDW IVDLRHELTH KKMPHINDCR RGCYFVLDWL QKTYWCRQLE NSLRETWELE EFREGIEEED QEEDKNIVVD DITEQKPEPQ DDGKSTESDV KADGDSKGSE EVDSHCKKAL SHKELYERAR ELLVSYEEEQ FTVLEKFRYL PKAIKAWNNP SPRVECVLAE LKGVTCENRE AVLDAFLDDG FLVPTFEQLA ALQIEYEDGQ TEVQRGEGTD PKSHKNVDLN DVLVPKPFSQ FWQPLLRGLH SQNFTQALLE RMLSELPALG ISGIRPTYIL RWTVELIVAN TKTGRNARRF SAGQWEARRG WRLFNCSASL DWPRMVESCL GSPCWASPQL LRIIFKAMGQ GLPDEEQEKL LRICSIYTQS GENSLVQEGS EASPIGKSPY TLDSLYWSVK PASSSFGSEA KAQQQEEQGS VNDVKEEEKE EKEVLPDQVE EEEENDDQEE EEEDEDDEDD EEEDRMEVGP FSTGQESPTA ENARLLAQKR GALQGSAWQV SSEDVRWDTF PLGRMPGQTE DPAELMLENY DTMYLLDQPV LEQRLEPSTC KTDTLGLSCG VGSGNCSNSS SSNFEGLLWS QGQLHGLKTG LQLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards