Mitochondrial inner membrane m-AAA protease component AFG3L2 (AFG3L2)
Homo sapiens — UniProt Q9Y4W6
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial inner membrane m-AAA protease component AFG3L2 (AFG3L2) is a protein from Homo sapiens identified by UniProt accession Q9Y4W6, 797 residues long. MolForge cross-references it against 0 known binders and 253 disease associations.
- UniProt accession: Q9Y4W6; gene symbol AFG3L2.
- Organism: Homo sapiens.
- Length: 797 amino acids.
- Top disease associations (Open Targets): spinocerebellar ataxia type 28, optic atrophy 12 and spastic ataxia 5.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial inner membrane m-AAA protease component AFG3L2 |
|---|---|
| UniProt accession | Q9Y4W6 |
| Gene | AFG3L2 |
| Organism | Homo sapiens |
| Length | 797 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (253)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia type 28 · score 0.83
- optic atrophy 12 · score 0.81
- spastic ataxia 5 · score 0.79
- Early-onset spastic ataxia-neuropathy syndrome · score 0.77
- autosomal recessive spastic ataxia · score 0.53
- optic atrophy · score 0.51
- Dystonia · score 0.45
- neurodegenerative disease · score 0.35
- Intellectual disability · score 0.34
- spastic ataxia · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4W6-F1 | alphafold | PREDICTED | 76.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4W6.
Amino-acid sequence (797 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AFG3L2?
The strongest Open Targets associations for AFG3L2 are spinocerebellar ataxia type 28, optic atrophy 12, spastic ataxia 5, Early-onset spastic ataxia-neuropathy syndrome and autosomal recessive spastic ataxia.
How long is the AFG3L2 protein?
The Homo sapiens AFG3L2 protein (UniProt Q9Y4W6) is 797 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4W6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4W6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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