Nuclear protein AMMECR1 (AMMECR1)
Homo sapiens — UniProt Q9Y4X0
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear protein AMMECR1 (AMMECR1) is a protein from Homo sapiens identified by UniProt accession Q9Y4X0, 333 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q9Y4X0; gene symbol AMMECR1.
- Organism: Homo sapiens.
- Length: 333 amino acids.
- Top disease associations (Open Targets): Alport syndrome - intellectual disability - midface hypoplasia - elliptocytosis, Short stature and Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear protein AMMECR1 |
|---|---|
| UniProt accession | Q9Y4X0 |
| Gene | AMMECR1 |
| Organism | Homo sapiens |
| Length | 333 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- Alport syndrome - intellectual disability - midface hypoplasia - elliptocytosis · score 0.65
- Short stature · score 0.45
- Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome · score 0.42
- neurodegenerative disease · score 0.19
- response to statin · score 0.09
- low density lipoprotein cholesterol measurement · score 0.08
- Disorder of lipid metabolism · score 0.07
- familial hypercholesterolemia · score 0.03
- psoriasis · score 0.02
- ovarian carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4X0-F1 | alphafold | PREDICTED | 71.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4X0.
Amino-acid sequence (333 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AMMECR1?
The strongest Open Targets associations for AMMECR1 are Alport syndrome - intellectual disability - midface hypoplasia - elliptocytosis, Short stature, Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome, neurodegenerative disease and response to statin.
How long is the AMMECR1 protein?
The Homo sapiens AMMECR1 protein (UniProt Q9Y4X0) is 333 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4X0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4X0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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