Krueppel-like factor 12 (KLF12)
Homo sapiens — UniProt Q9Y4X4
Data last refreshed: (UniProt release unknown)
Key facts
Krueppel-like factor 12 (KLF12) is a protein from Homo sapiens identified by UniProt accession Q9Y4X4, 402 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.
- UniProt accession: Q9Y4X4; gene symbol KLF12.
- Organism: Homo sapiens.
- Length: 402 amino acids.
- Top disease associations (Open Targets): electrocardiography, lymphocyte count and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Krueppel-like factor 12 |
|---|---|
| UniProt accession | Q9Y4X4 |
| Gene | KLF12 |
| Organism | Homo sapiens |
| Length | 402 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (153)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.54
- lymphocyte count · score 0.52
- mean platelet volume · score 0.50
- QRS duration · score 0.49
- age at menarche · score 0.47
- QT interval · score 0.47
- heel bone mineral density · score 0.47
- leukocyte count · score 0.47
- eosinophil count · score 0.46
- neutrophil percentage of leukocytes · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4X4-F1 | alphafold | PREDICTED | 50.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4X4.
Amino-acid sequence (402 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLF12?
The strongest Open Targets associations for KLF12 are electrocardiography, lymphocyte count, mean platelet volume, QRS duration and age at menarche.
How long is the KLF12 protein?
The Homo sapiens KLF12 protein (UniProt Q9Y4X4) is 402 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4X4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4X4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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