E3 ubiquitin-protein ligase ARIH1 (ARIH1)
Homo sapiens — UniProt Q9Y4X5
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase ARIH1 (ARIH1) is a protein from Homo sapiens identified by UniProt accession Q9Y4X5, 557 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.
- UniProt accession: Q9Y4X5; gene symbol ARIH1.
- Organism: Homo sapiens.
- Length: 557 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, aortic aneurysm and thoracic aortic aneurysm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase ARIH1 |
|---|---|
| UniProt accession | Q9Y4X5 |
| Gene | ARIH1 |
| Organism | Homo sapiens |
| Length | 557 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (65)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- aortic aneurysm · score 0.45
- thoracic aortic aneurysm · score 0.42
- body height · score 0.24
- neoplasm · score 0.10
- platelet count · score 0.10
- brain measurement · score 0.07
- cancer · score 0.07
- breast cancer · score 0.05
- acheiropody · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4X5-F1 | alphafold | PREDICTED | 79.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4X5.
Amino-acid sequence (557 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARIH1?
The strongest Open Targets associations for ARIH1 are neurodegenerative disease, aortic aneurysm, thoracic aortic aneurysm, body height and neoplasm.
How long is the ARIH1 protein?
The Homo sapiens ARIH1 protein (UniProt Q9Y4X5) is 557 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4X5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4X5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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