U6 snRNA-associated Sm-like protein LSm5 (LSM5)
Homo sapiens — UniProt Q9Y4Y9
Data last refreshed: (UniProt release unknown)
Key facts
U6 snRNA-associated Sm-like protein LSm5 (LSM5) is a protein from Homo sapiens identified by UniProt accession Q9Y4Y9, 91 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q9Y4Y9; gene symbol LSM5.
- Organism: Homo sapiens.
- Length: 91 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, intelligence and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | U6 snRNA-associated Sm-like protein LSm5 |
|---|---|
| UniProt accession | Q9Y4Y9 |
| Gene | LSM5 |
| Organism | Homo sapiens |
| Length | 91 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- intelligence · score 0.25
- self reported educational attainment · score 0.25
- mathematical ability · score 0.24
- schizophrenia · score 0.14
- cognitive function measurement · score 0.13
- body height · score 0.13
- Red cell distribution width · score 0.10
- PHF-tau measurement · score 0.05
- gonorrhea · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4Y9-F1 | alphafold | PREDICTED | 90.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4Y9.
Amino-acid sequence (91 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LSM5?
The strongest Open Targets associations for LSM5 are neurodegenerative disease, intelligence, self reported educational attainment, mathematical ability and schizophrenia.
How long is the LSM5 protein?
The Homo sapiens LSM5 protein (UniProt Q9Y4Y9) is 91 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4Y9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4Y9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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