U6 snRNA-associated Sm-like protein LSm4 (LSM4)
Homo sapiens — UniProt Q9Y4Z0
Data last refreshed: (UniProt release unknown)
Key facts
U6 snRNA-associated Sm-like protein LSm4 (LSM4) is a protein from Homo sapiens identified by UniProt accession Q9Y4Z0, 139 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q9Y4Z0; gene symbol LSM4.
- Organism: Homo sapiens.
- Length: 139 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular volume and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | U6 snRNA-associated Sm-like protein LSm4 |
|---|---|
| UniProt accession | Q9Y4Z0 |
| Gene | LSM4 |
| Organism | Homo sapiens |
| Length | 139 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- mean corpuscular volume · score 0.25
- erythrocyte count · score 0.24
- monocyte count · score 0.22
- mean corpuscular hemoglobin · score 0.21
- mean corpuscular hemoglobin concentration · score 0.21
- red blood cell density measurement · score 0.19
- platelet component distribution width · score 0.18
- reticulocyte count · score 0.18
- neutrophil count · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y4Z0-F1 | alphafold | PREDICTED | 75.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y4Z0.
Amino-acid sequence (139 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LSM4?
The strongest Open Targets associations for LSM4 are neurodegenerative disease, mean corpuscular volume, erythrocyte count, monocyte count and mean corpuscular hemoglobin.
How long is the LSM4 protein?
The Homo sapiens LSM4 protein (UniProt Q9Y4Z0) is 139 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y4Z0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y4Z0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.