Transcription factor HES-2 (HES2)
Homo sapiens — UniProt Q9Y543
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor HES-2 (HES2) is a protein from Homo sapiens identified by UniProt accession Q9Y543, 173 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q9Y543; gene symbol HES2.
- Organism: Homo sapiens.
- Length: 173 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, BMI-adjusted waist circumference and central nervous system cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor HES-2 |
|---|---|
| UniProt accession | Q9Y543 |
| Gene | HES2 |
| Organism | Homo sapiens |
| Length | 173 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- BMI-adjusted waist circumference · score 0.04
- central nervous system cancer · score 0.04
- acute lymphoblastic leukemia · score 0.02
- Down syndrome · score 0.02
- endometriosis · score 0.01
- Crohn's disease · score 0.01
- neuroblastoma · score 0.01
- Obesity · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y543-F1 | alphafold | PREDICTED | 73.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y543.
Amino-acid sequence (173 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HES2?
The strongest Open Targets associations for HES2 are neurodegenerative disease, BMI-adjusted waist circumference, central nervous system cancer, acute lymphoblastic leukemia and Down syndrome.
How long is the HES2 protein?
The Homo sapiens HES2 protein (UniProt Q9Y543) is 173 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y543 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y543 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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