Intraflagellar transport protein 25 homolog (IFT25)
Homo sapiens — UniProt Q9Y547
Data last refreshed: (UniProt release unknown)
Key facts
Intraflagellar transport protein 25 homolog (IFT25) is a protein from Homo sapiens identified by UniProt accession Q9Y547, 144 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.
- UniProt accession: Q9Y547; gene symbol IFT25.
- Organism: Homo sapiens.
- Length: 144 amino acids.
- Top disease associations (Open Targets): renal agenesis, thyroxine measurement and hormone measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Intraflagellar transport protein 25 homolog |
|---|---|
| UniProt accession | Q9Y547 |
| Gene | IFT25 |
| Organism | Homo sapiens |
| Length | 144 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (153)
Diseases linked to this target (Open Targets).
- renal agenesis · score 0.11
- thyroxine measurement · score 0.10
- hormone measurement · score 0.10
- hepatocellular carcinoma · score 0.08
- congenital absence of upper arm and forearm with hand present · score 0.06
- hypertriglyceridemia 2 · score 0.06
- cholesterol-ester transfer protein deficiency · score 0.05
- Heterotaxia · score 0.05
- pentalogy of Cantrell · score 0.05
- lung agenesis-heart defect-thumb anomalies syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y547-F1 | alphafold | PREDICTED | 93.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y547.
Amino-acid sequence (144 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IFT25?
The strongest Open Targets associations for IFT25 are renal agenesis, thyroxine measurement, hormone measurement, hepatocellular carcinoma and congenital absence of upper arm and forearm with hand present.
How long is the IFT25 protein?
The Homo sapiens IFT25 protein (UniProt Q9Y547) is 144 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y547 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y547 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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