Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
Homo sapiens — UniProt Q9Y572
Data last refreshed: (UniProt release unknown)
Key facts
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) is a protein from Homo sapiens identified by UniProt accession Q9Y572, 518 residues long. MolForge cross-references it against 20 known binders and 442 disease associations.
- UniProt accession: Q9Y572; gene symbol RIPK3.
- Organism: Homo sapiens.
- Length: 518 amino acids.
- Approved drugs acting on it (DrugCentral): Ponatinib.
- Top disease associations (Open Targets): severe acute respiratory syndrome, viral disease and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Receptor-interacting serine/threonine-protein kinase 3 |
|---|---|
| UniProt accession | Q9Y572 |
| Gene | RIPK3 |
| Organism | Homo sapiens |
| Length | 518 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (442)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.53
- viral disease · score 0.38
- hemoglobin measurement · score 0.33
- hematocrit · score 0.32
- heel bone mineral density · score 0.27
- Agents acting on the renin-angiotensin system use measurement · score 0.21
- red blood cell density measurement · score 0.21
- glioblastoma multiforme · score 0.19
- lung adenocarcinoma · score 0.19
- ovarian cancer · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y572-F1 | alphafold | PREDICTED | 67.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y572.
Amino-acid sequence (518 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target RIPK3?
DrugCentral lists 1 approved drug whose mechanism of action is RIPK3: Ponatinib.
Which diseases are associated with RIPK3?
The strongest Open Targets associations for RIPK3 are severe acute respiratory syndrome, viral disease, hemoglobin measurement, hematocrit and heel bone mineral density.
How long is the RIPK3 protein?
The Homo sapiens RIPK3 protein (UniProt Q9Y572) is 518 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y572 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y572 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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