NEDD8 ultimate buster 1 (NUB1)
Homo sapiens — UniProt Q9Y5A7
Data last refreshed: (UniProt release unknown)
Key facts
NEDD8 ultimate buster 1 (NUB1) is a protein from Homo sapiens identified by UniProt accession Q9Y5A7, 615 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q9Y5A7; gene symbol NUB1.
- Organism: Homo sapiens.
- Length: 615 amino acids.
- Top disease associations (Open Targets): body height, platelet crit and renal cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NEDD8 ultimate buster 1 |
|---|---|
| UniProt accession | Q9Y5A7 |
| Gene | NUB1 |
| Organism | Homo sapiens |
| Length | 615 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- body height · score 0.27
- platelet crit · score 0.20
- renal cell carcinoma · score 0.05
- 22q11.2 deletion syndrome · score 0.04
- immunodeficiency 80 with or without congenital cardiomyopathy · score 0.04
- retinitis pigmentosa and erythrocytic microcytosis · score 0.04
- cancer · score 0.04
- Chronic mucocutaneous candidosis · score 0.04
- lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome · score 0.04
- Lung fibrosis - immunodeficiency - 46,XX gonadal dysgenesis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5A7-F1 | alphafold | PREDICTED | 83.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5A7.
Amino-acid sequence (615 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUB1?
The strongest Open Targets associations for NUB1 are body height, platelet crit, renal cell carcinoma, 22q11.2 deletion syndrome and immunodeficiency 80 with or without congenital cardiomyopathy.
How long is the NUB1 protein?
The Homo sapiens NUB1 protein (UniProt Q9Y5A7) is 615 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5A7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5A7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.