YTH domain-containing family protein 2 (YTHDF2)
Homo sapiens — UniProt Q9Y5A9
Data last refreshed: (UniProt release unknown)
Key facts
YTH domain-containing family protein 2 (YTHDF2) is a protein from Homo sapiens identified by UniProt accession Q9Y5A9, 579 residues long. MolForge cross-references it against 0 known binders and 298 disease associations.
- UniProt accession: Q9Y5A9; gene symbol YTHDF2.
- Organism: Homo sapiens.
- Length: 579 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, type 2 diabetes mellitus and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | YTH domain-containing family protein 2 |
|---|---|
| UniProt accession | Q9Y5A9 |
| Gene | YTHDF2 |
| Organism | Homo sapiens |
| Length | 579 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (298)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- type 2 diabetes mellitus · score 0.19
- body height · score 0.17
- hemoglobin A1 measurement · score 0.16
- basophil count · score 0.14
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.11
- cancer · score 0.11
- erythrocyte count · score 0.11
- acute myeloid leukemia · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5A9-F1 | alphafold | PREDICTED | 59.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5A9.
Amino-acid sequence (579 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with YTHDF2?
The strongest Open Targets associations for YTHDF2 are neurodegenerative disease, type 2 diabetes mellitus, body height, hemoglobin A1 measurement and basophil count.
How long is the YTHDF2 protein?
The Homo sapiens YTHDF2 protein (UniProt Q9Y5A9) is 579 amino acids long.
Browse: Targets: Y · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5A9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5A9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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