RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1)
Homo sapiens — UniProt Q9Y5B0
Data last refreshed: (UniProt release unknown)
Key facts
RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) is a protein from Homo sapiens identified by UniProt accession Q9Y5B0, 961 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q9Y5B0; gene symbol CTDP1.
- Organism: Homo sapiens.
- Length: 961 amino acids.
- Top disease associations (Open Targets): Congenital cataracts - facial dysmorphism - neuropathy, HIV infection and congenital cataracts-facial dysmorphism-neuropathy syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA polymerase II subunit A C-terminal domain phosphatase |
|---|---|
| UniProt accession | Q9Y5B0 |
| Gene | CTDP1 |
| Organism | Homo sapiens |
| Length | 961 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- Congenital cataracts - facial dysmorphism - neuropathy · score 0.70
- HIV infection · score 0.59
- congenital cataracts-facial dysmorphism-neuropathy syndrome · score 0.57
- neurodegenerative disease · score 0.44
- monocyte count · score 0.42
- neuroinflammatory disorder · score 0.37
- mean corpuscular volume · score 0.36
- Charcot-Marie-Tooth disease · score 0.33
- smoking initiation · score 0.31
- mean corpuscular hemoglobin · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5B0-F1 | alphafold | PREDICTED | 63.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5B0.
Amino-acid sequence (961 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CTDP1?
The strongest Open Targets associations for CTDP1 are Congenital cataracts - facial dysmorphism - neuropathy, HIV infection, congenital cataracts-facial dysmorphism-neuropathy syndrome, neurodegenerative disease and monocyte count.
How long is the CTDP1 protein?
The Homo sapiens CTDP1 protein (UniProt Q9Y5B0) is 961 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5B0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5B0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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