PAX3- and PAX7-binding protein 1 (PAXBP1)
Homo sapiens — UniProt Q9Y5B6
Data last refreshed: (UniProt release unknown)
Key facts
PAX3- and PAX7-binding protein 1 (PAXBP1) is a protein from Homo sapiens identified by UniProt accession Q9Y5B6, 917 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q9Y5B6; gene symbol PAXBP1.
- Organism: Homo sapiens.
- Length: 917 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, self reported educational attainment and gastroesophageal reflux disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PAX3- and PAX7-binding protein 1 |
|---|---|
| UniProt accession | Q9Y5B6 |
| Gene | PAXBP1 |
| Organism | Homo sapiens |
| Length | 917 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.41
- self reported educational attainment · score 0.23
- gastroesophageal reflux disease · score 0.20
- mean corpuscular volume · score 0.17
- cortical surface area measurement · score 0.13
- Myopia · score 0.11
- pathological myopia · score 0.11
- cortical thickness · score 0.07
- body mass index · score 0.02
- ovarian carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5B6-F1 | alphafold | PREDICTED | 71.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5B6.
Amino-acid sequence (917 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PAXBP1?
The strongest Open Targets associations for PAXBP1 are neurodegenerative disease, self reported educational attainment, gastroesophageal reflux disease, mean corpuscular volume and cortical surface area measurement.
How long is the PAXBP1 protein?
The Homo sapiens PAXBP1 protein (UniProt Q9Y5B6) is 917 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5B6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5B6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.