FACT complex subunit SPT16 (SUPT16H)
Homo sapiens — UniProt Q9Y5B9
Data last refreshed: (UniProt release unknown)
Key facts
FACT complex subunit SPT16 (SUPT16H) is a protein from Homo sapiens identified by UniProt accession Q9Y5B9, 1047 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.
- UniProt accession: Q9Y5B9; gene symbol SUPT16H.
- Organism: Homo sapiens.
- Length: 1047 amino acids.
- Top disease associations (Open Targets): HIV infection, Global developmental delay and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | FACT complex subunit SPT16 |
|---|---|
| UniProt accession | Q9Y5B9 |
| Gene | SUPT16H |
| Organism | Homo sapiens |
| Length | 1047 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (78)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.58
- Global developmental delay · score 0.37
- Intellectual disability · score 0.37
- Abnormal corpus callosum morphology · score 0.37
- neurodegenerative disease · score 0.31
- low grade glioma · score 0.26
- glioblastoma multiforme · score 0.26
- breast adenocarcinoma · score 0.26
- ovarian cancer · score 0.25
- calcium measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5B9-F1 | alphafold | PREDICTED | 79.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5B9.
Amino-acid sequence (1047 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SUPT16H?
The strongest Open Targets associations for SUPT16H are HIV infection, Global developmental delay, Intellectual disability, Abnormal corpus callosum morphology and neurodegenerative disease.
How long is the SUPT16H protein?
The Homo sapiens SUPT16H protein (UniProt Q9Y5B9) is 1047 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5B9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5B9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.