Angiopoietin-related protein 3 (ANGPTL3)
Homo sapiens — UniProt Q9Y5C1
Data last refreshed: (UniProt release unknown)
Key facts
Angiopoietin-related protein 3 (ANGPTL3) is a protein from Homo sapiens identified by UniProt accession Q9Y5C1, 460 residues long. MolForge cross-references it against 1 known binders and 416 disease associations.
- UniProt accession: Q9Y5C1; gene symbol ANGPTL3.
- Organism: Homo sapiens.
- Length: 460 amino acids.
- Approved drugs acting on it (DrugCentral): Evinacumab.
- Top disease associations (Open Targets): familial hypobetalipoproteinemia 2, triglyceride measurement and total cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Angiopoietin-related protein 3 |
|---|---|
| UniProt accession | Q9Y5C1 |
| Gene | ANGPTL3 |
| Organism | Homo sapiens |
| Length | 460 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (416)
Diseases linked to this target (Open Targets).
- familial hypobetalipoproteinemia 2 · score 0.67
- triglyceride measurement · score 0.64
- total cholesterol measurement · score 0.63
- low density lipoprotein cholesterol measurement · score 0.63
- very low density lipoprotein cholesterol measurement · score 0.61
- high density lipoprotein cholesterol measurement · score 0.60
- cholesteryl ester measurement · score 0.60
- lipoprotein measurement · score 0.59
- apolipoprotein B measurement · score 0.58
- phospholipids in medium VLDL measurement · score 0.58
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5C1-F1 | alphafold | PREDICTED | 79.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5C1.
Amino-acid sequence (460 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target ANGPTL3?
DrugCentral lists 1 approved drug whose mechanism of action is ANGPTL3: Evinacumab.
Which diseases are associated with ANGPTL3?
The strongest Open Targets associations for ANGPTL3 are familial hypobetalipoproteinemia 2, triglyceride measurement, total cholesterol measurement, low density lipoprotein cholesterol measurement and very low density lipoprotein cholesterol measurement.
How long is the ANGPTL3 protein?
The Homo sapiens ANGPTL3 protein (UniProt Q9Y5C1) is 460 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5C1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5C1 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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