Protocadherin beta-5 (PCDHB5)
Homo sapiens — UniProt Q9Y5E4
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin beta-5 (PCDHB5) is a protein from Homo sapiens identified by UniProt accession Q9Y5E4, 795 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q9Y5E4; gene symbol PCDHB5.
- Organism: Homo sapiens.
- Length: 795 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Blackfan-Diamond anemia and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin beta-5 |
|---|---|
| UniProt accession | Q9Y5E4 |
| Gene | PCDHB5 |
| Organism | Homo sapiens |
| Length | 795 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- Blackfan-Diamond anemia · score 0.07
- leukocyte count · score 0.06
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
- hemoglobin D disease · score 0.05
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.05
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.05
- delta-beta-thalassemia · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- dominant beta-thalassemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5E4-F1 | alphafold | PREDICTED | 81.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5E4.
Amino-acid sequence (795 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHB5?
The strongest Open Targets associations for PCDHB5 are neurodegenerative disease, Blackfan-Diamond anemia, leukocyte count, hereditary persistence of fetal hemoglobin-sickle cell disease syndrome and hemoglobin D disease.
How long is the PCDHB5 protein?
The Homo sapiens PCDHB5 protein (UniProt Q9Y5E4) is 795 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5E4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5E4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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