Protocadherin beta-4 (PCDHB4)
Homo sapiens — UniProt Q9Y5E5
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin beta-4 (PCDHB4) is a protein from Homo sapiens identified by UniProt accession Q9Y5E5, 795 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q9Y5E5; gene symbol PCDHB4.
- Organism: Homo sapiens.
- Length: 795 amino acids.
- Top disease associations (Open Targets): Microcephaly, Intellectual disability and Seizure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin beta-4 |
|---|---|
| UniProt accession | Q9Y5E5 |
| Gene | PCDHB4 |
| Organism | Homo sapiens |
| Length | 795 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- Microcephaly · score 0.26
- Intellectual disability · score 0.26
- Seizure · score 0.26
- leukocyte count · score 0.15
- Brugada syndrome · score 0.05
- Familial progressive cardiac conduction defect · score 0.05
- hypertrophic cardiomyopathy · score 0.04
- progressive familial heart block, type 1A · score 0.04
- familial atrial fibrillation · score 0.04
- dilated cardiomyopathy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5E5-F1 | alphafold | PREDICTED | 82.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5E5.
Amino-acid sequence (795 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHB4?
The strongest Open Targets associations for PCDHB4 are Microcephaly, Intellectual disability, Seizure, leukocyte count and Brugada syndrome.
How long is the PCDHB4 protein?
The Homo sapiens PCDHB4 protein (UniProt Q9Y5E5) is 795 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5E5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5E5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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