Protocadherin beta-15 (PCDHB15)
Homo sapiens — UniProt Q9Y5E8
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin beta-15 (PCDHB15) is a protein from Homo sapiens identified by UniProt accession Q9Y5E8, 787 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q9Y5E8; gene symbol PCDHB15.
- Organism: Homo sapiens.
- Length: 787 amino acids.
- Top disease associations (Open Targets): Blackfan-Diamond anemia, body height and primary familial polycythemia due to EPO receptor mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin beta-15 |
|---|---|
| UniProt accession | Q9Y5E8 |
| Gene | PCDHB15 |
| Organism | Homo sapiens |
| Length | 787 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- Blackfan-Diamond anemia · score 0.07
- body height · score 0.07
- primary familial polycythemia due to EPO receptor mutation · score 0.06
- melanoma · score 0.05
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.05
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.05
- hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.05
- Pyruvate kinase hyperactivity · score 0.05
- erythrocytosis, familial, 3 · score 0.05
- Constitutional sideroblastic anemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5E8-F1 | alphafold | PREDICTED | 81.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5E8.
Amino-acid sequence (787 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHB15?
The strongest Open Targets associations for PCDHB15 are Blackfan-Diamond anemia, body height, primary familial polycythemia due to EPO receptor mutation, melanoma and Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16.
How long is the PCDHB15 protein?
The Homo sapiens PCDHB15 protein (UniProt Q9Y5E8) is 787 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5E8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5E8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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