Protocadherin gamma-A8 (PCDHGA8)
Homo sapiens — UniProt Q9Y5G5
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin gamma-A8 (PCDHGA8) is a protein from Homo sapiens identified by UniProt accession Q9Y5G5, 932 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q9Y5G5; gene symbol PCDHGA8.
- Organism: Homo sapiens.
- Length: 932 amino acids.
- Top disease associations (Open Targets): mean platelet volume, genetic disorder and Neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin gamma-A8 |
|---|---|
| UniProt accession | Q9Y5G5 |
| Gene | PCDHGA8 |
| Organism | Homo sapiens |
| Length | 932 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.28
- genetic disorder · score 0.19
- Neurodevelopmental disorder · score 0.12
- self reported educational attainment · score 0.11
- body mass index · score 0.03
- triglyceride measurement · score 0.03
- refractive error measurement · score 0.02
- mathematical ability · score 0.02
- Pick disease · score 0.01
- endometrial carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5G5-F1 | alphafold | PREDICTED | 73.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5G5.
Amino-acid sequence (932 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHGA8?
The strongest Open Targets associations for PCDHGA8 are mean platelet volume, genetic disorder, Neurodevelopmental disorder, self reported educational attainment and body mass index.
How long is the PCDHGA8 protein?
The Homo sapiens PCDHGA8 protein (UniProt Q9Y5G5) is 932 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5G5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5G5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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