Protocadherin gamma-A5 (PCDHGA5)
Homo sapiens — UniProt Q9Y5G8
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin gamma-A5 (PCDHGA5) is a protein from Homo sapiens identified by UniProt accession Q9Y5G8, 931 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q9Y5G8; gene symbol PCDHGA5.
- Organism: Homo sapiens.
- Length: 931 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, genetic disorder and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin gamma-A5 |
|---|---|
| UniProt accession | Q9Y5G8 |
| Gene | PCDHGA5 |
| Organism | Homo sapiens |
| Length | 931 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.25
- genetic disorder · score 0.19
- mean platelet volume · score 0.13
- Neurodevelopmental disorder · score 0.12
- self reported educational attainment · score 0.04
- refractive error measurement · score 0.02
- Intellectual disability · score 0.01
- endometrial carcinoma · score 0.00
- head and neck squamous cell carcinoma · score 0.00
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5G8-F1 | alphafold | PREDICTED | 74.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5G8.
Amino-acid sequence (931 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHGA5?
The strongest Open Targets associations for PCDHGA5 are neurodegenerative disease, genetic disorder, mean platelet volume, Neurodevelopmental disorder and self reported educational attainment.
How long is the PCDHGA5 protein?
The Homo sapiens PCDHGA5 protein (UniProt Q9Y5G8) is 931 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5G8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5G8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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