Protocadherin gamma-A4 (PCDHGA4)
Homo sapiens — UniProt Q9Y5G9
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin gamma-A4 (PCDHGA4) is a protein from Homo sapiens identified by UniProt accession Q9Y5G9, 962 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q9Y5G9; gene symbol PCDHGA4.
- Organism: Homo sapiens.
- Length: 962 amino acids.
- Top disease associations (Open Targets): genetic disorder, neurodegenerative disease and Neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin gamma-A4 |
|---|---|
| UniProt accession | Q9Y5G9 |
| Gene | PCDHGA4 |
| Organism | Homo sapiens |
| Length | 962 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.19
- neurodegenerative disease · score 0.16
- Neurodevelopmental disorder · score 0.12
- mean platelet volume · score 0.10
- self reported educational attainment · score 0.05
- colorectal adenocarcinoma · score 0.04
- refractive error measurement · score 0.02
- atrial heart septal defect · score 0.01
- metopic craniosynostosis · score 0.00
- neuroblastoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5G9-F1 | alphafold | PREDICTED | 73.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5G9.
Amino-acid sequence (962 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHGA4?
The strongest Open Targets associations for PCDHGA4 are genetic disorder, neurodegenerative disease, Neurodevelopmental disorder, mean platelet volume and self reported educational attainment.
How long is the PCDHGA4 protein?
The Homo sapiens PCDHGA4 protein (UniProt Q9Y5G9) is 962 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5G9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5G9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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